- Fox is new with Are You Smarter Than a 5th Grader?
- NBC is new with Stand Up to Cancer, NFL Opening Kickoff 2008, and Dateline
- CBS is new with Stand Up to Cancer, has the CBS Fall Preview, and is new with Swingtown
- ABC is new with Stand Up to Cancer, has a repeat of America's Funniest Home Videos, and is new with 20/20
- The CW is new with Friday Night SmackDown
- USA is new with Monk and Psych
- MTV has Exiled
- VH1 has Drug Years
- E! is new with Stand Up to Cancer and The Soup
- Late-night highlights include John Malkovich, Hayden Panettiere, and Steve Earle on Late Show With David Letterman on CBS; Eva Mendes, Chris Matthews, and Shinedown on The Tonight Show With Jay Leno on NBC; and Jerry O'Connell and Christian Lander on Late Night With Conan O'Brien on NBC
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wow, stand up to cancer is the big thing tonight, huh. Good for that.